The Peptide Reference
The Peptide Reference
References
Best for/Metabolic & weight

Metabolic & weight

GLP-1 class and adjacent metabolic peptides, plus body-composition research.

Ranking reflects how much cited material this reference holds for the goal — how many indications are recorded and how strong the reported effects were. It is a measure of documentation, not a safety or efficacy endorsement, and a compound can rank highly on preclinical work alone.
1
Retatrutide
Triple GLP-1/GIP/glucagon agonist

Glucose-Dependent Regulation · Triple Mechanism · Superior Glycemic Control · Insulin Sensitivity · +5 more

9 indications · 6 refs
2
Semaglutide
GLP-1 receptor agonist

NASH/Fatty Liver · Sustained Weight Maintenance · Glycemic Control · Appetite and Craving Control · +5 more

9 indications · 9 refs
3
Tesamorelin
GHRH analog

Lean Mass Preservation · IGF-1 Elevation · Sustained Fat Loss · NAFLD Treatment · +4 more

8 indications · 5 refs
4
Tirzepatide
Dual GLP-1/GIP agonist

Body Composition Optimization · Insulin Resistance Improvement · Beta Cell Preservation · Metabolic Syndrome Reversal · +2 more

6 indications · 8 refs
5
Cagrilintide
Amylin receptor agonist

Obesity (CagriSema Combination) · Weight Loss in Diabetic Patients · Glycemic Control · Obesity (Monotherapy) · +2 more

6 indications · 3 refs
6
SLU-PP-332
Synthetic ERR agonist

Energy Expenditure Enhancement · Liver Health & NAFLD · Insulin Sensitivity & Glucose Control · Weight Loss & Body Composition

4 indications · 4 refs
7
Survodutide
Peptide with fatty acid acylation

Obesity Without Diabetes · Obesity With Type 2 Diabetes · Sustained Weight Management · MASH Treatment · +2 more

6 indications · 0 refs
8
Orforglipron
Small-molecule GLP-1R agonist

Obesity Without Diabetes · Obesity With Type 2 Diabetes · Cardiometabolic Risk Reduction · Prediabetes Prevention · +2 more

6 indications · 0 refs
9
Mazdutide
Oxyntomodulin analog with fatty acid conjugation

Liver Fat Reduction · Glycemic Control · Dual Endpoint Achievement · Metabolic Syndrome Improvement · +1 more

5 indications · 0 refs
10
Tesa/IPA Protocol
Dual GH secretagogue combination

Visceral Fat Loss · Lipid Profile · Lean Mass Support · IGF-1 Optimization · +1 more

5 indications · 2 refs
11
NAD+
Coenzyme

Metabolic Optimization · Cellular Energy Production · Exercise Performance

3 indications · 6 refs
12
SS-31
Aromatic-cationic tetrapeptide

Enhanced ATP Production · Oxidative Stress Reduction · Mitochondrial Disease Support

3 indications · 6 refs
13
MOTS-c
Mitochondrial-derived peptide (MDP)

Obesity Prevention · Insulin Resistance · Type 2 Diabetes Support

3 indications · 5 refs
14
5-Amino-1MQ
Small molecule NNMT enzyme inhibitor

Metabolic Flexibility · Fat Oxidation · Energy Metabolism · Insulin Sensitivity · +1 more

5 indications · 3 refs
15
MK-677
Non-peptide ghrelin receptor agonist

Metabolic Rate · Fat-Free Mass · Muscle Preservation

3 indications · 7 refs
16
AOD-9604
Modified hGH C-terminal fragment

Lipolysis Enhancement · Lipogenesis Inhibition · Metabolic Safety

3 indications · 5 refs
17
HGH Fragment 176-191
hGH C-terminal fragment (176-191)

Body Composition · Lipolysis Enhancement · Lipogenesis Inhibition

3 indications · 4 refs
18
Pancragen
Tetrapeptide bioregulator

Impaired Glucose Tolerance · Metabolic Syndrome · Blood Sugar Regulation · Pancreatic Cell Differentiation · +2 more

6 indications · 0 refs
19
HGH
Single-chain polypeptide with two disulfide bridges

Lean Mass · Fat Loss · Recovery Enhancement

3 indications · 4 refs
20
BAM-15
Small molecule (not a peptide)

Insulin Resistance · Metabolic Syndrome · Obesity/Fat Loss

3 indications · 4 refs
21
Ipamorelin
Growth hormone secretagogue

Lean Mass Development · Fat Loss Support

2 indications · 5 refs
22
AICAR
Nucleoside analog

AMPK Activation · Fatty Acid Oxidation · Glucose Metabolism

3 indications · 0 refs
23
GHRP-6
Synthetic hexapeptide

Recovery Enhancement · Muscle Growth · Appetite Stimulation

3 indications · 0 refs
24
CJC-1295 with DAC
GHRH analog with DAC

Fat Loss Enhancement · Lean Mass Gains

2 indications · 4 refs
25
CJC/IPA Protocol
Peptide combination (GHRH analog + GHS)

Metabolic Flexibility · Body Composition Support

2 indications · 4 refs
26
Adipotide
Chimeric peptidomimetic

Adipose Mass Reduction · Insulin Resistance · Non-CNS Mechanism

3 indications · 0 refs
27
L-Carnitine
Quaternary ammonium compound

Fatty Acid Oxidation · Weight Management · Energy Production

3 indications · 0 refs
28
GHRP-2
Synthetic hexapeptide

Fat Metabolism · Recovery Enhancement · Muscle Growth

3 indications · 0 refs
29
ACE-031
Soluble activin receptor type IIB-Fc fusion protein

Fat Loss · Bone Density

2 indications · 4 refs
30
Cyclic Glycine-Proline
Cyclic dipeptide (2,5-diketopiperazine)

Blood Pressure Regulation · Type-2 Diabetes

2 indications · 4 refs
31
IGF-1 LR3
Synthetic IGF-1 analog

Fat Loss · Nutrient Partitioning

2 indications · 4 refs
32
Melanotan II
Synthetic alpha-MSH analog

Appetite Suppression · Fat Loss Support

2 indications · 4 refs
33
VIP
Neuropeptide

Anti-Inflammatory · Sarcoidosis · Diabetes Support

3 indications · 0 refs
34
Hexarelin
Synthetic hexapeptide

Fat Metabolism · Body Composition

2 indications · 0 refs
35
Kisspeptin
Neuropeptide family (RFamide)

Energy Metabolism

1 indication · 4 refs