Immune

Synthetic tetrapeptide from the Russian scientist Vladimir Khavinson, with more than 35 years of research behind it. Telomerase is activated at extremely low concentrations, holding telomere length; melatonin production is stimulated; gene expression is modulated by epigenetic mechanisms.

Synthetic heptapeptide analog of tuftsin, an immune peptide that occurs naturally; the Russian Academy of Sciences developed it. Anxiolytic effects are comparable to those of benzodiazepines, but sedation, amnesia, tolerance, and withdrawal do not follow.

Khavinson bioregulator made of glutamic acid and tryptophan — the EW dipeptide — first isolated in the late 1980s from Thymalin, an extract of calf thymus. Professor Vladimir Khavinson developed it; Russia has had it registered since 1990, in an injectable solution, a nasal spray, and a topical cream. Immunity is modulated on both the humoral and the cellular side, T-cell differentiation is activated, and research studies have shown antitumor and geroprotective (anti-aging) activities.

Synthetic 28-amino acid peptide identical to the thymic hormone that occurs naturally. More than 11,000 patients across upwards of 30 clinical trials have been studied, with serious adverse events under 1%. Immune modulation is the approved use, in more than 35 countries.

Khavinson bioregulator tetrapeptide (AEDL) whose primary effects fall on the bronchopulmonary system. It came out of Professor Vladimir Khavinson's group at Russia's St. Petersburg Institute of Bioregulation and Gerontology, targets bronchial tissue, and supports respiratory function. As with the other Khavinson peptides, it enters the cell nucleus and influences gene expression tied to maintenance and repair of respiratory tissue.

Tripeptide bioregulator (EDG) of the Khavinson series, sourced from lung tissue of the respiratory tract. It came out of Russia's St. Petersburg Institute of Bioregulation and Gerontology; the bronchopulmonary system is its target, and it carries secondary activity in the GI tract. Genes tied to proliferation responses, antioxidant activity, and inflammation are regulated, research shows. Monocyte TNF production is inhibited. Study has also treated it as a potential geroprotective agent, one that may support lung function where COPD and similar conditions are present.

Khavinson bioregulator tripeptide (EDP), identified in thymalin, acting selectively on thymus tissues. Developed at Russia's St. Petersburg Institute of Bioregulation and Gerontology, it raises immune function by stimulating proliferation of normal lymphocytes while holding back tumor cell growth. Research records immunity normalized in 82% of elderly patients against 56% of controls, and fewer respiratory infections in athletes, with HSP gene expression doubled.

Tripeptide taken from the C-terminal end of alpha-MSH, potent as an anti-inflammatory. It carries anti-inflammatory and antimicrobial properties but not the pigmentation effects of full α-MSH, which suits it to inflammation management.

Tetrapeptide bioregulator (KEDA) of the Khavinson series, immunomodulatory and hepatoprotective to a significant degree. Structurally it is close to Epitalon. Antioxidant and immune status are normalized, and liver function is restored in conditions of hepatitis. Its best-known property is the decondensation of chromatin: silent genes, among them ribosomal genes, switch on, and protein synthesis and cellular activity rise. Aging is when the protective effects peak.

Enhanced form of Selank, the anxiolytic nootropic peptide out of Russia's Institute of Molecular Genetics. An N-acetyl group improves blood-brain barrier penetration and yields more stable metabolites, and C-terminal amidation adds further metabolic stability and receptor binding. Anxiety relief comes without the sedation, dependency, or cognitive impairment that attend benzodiazepines.

Peptide of 43 amino acids, naturally occurring, central to tissue repair, wound healing, and cellular regeneration. It drives angiogenesis, lowers inflammation, and supports the migration and differentiation of cells.

Nonapeptide hormone secreted only by thymic epithelial cells, discovered by Jean-François Bach in the 1970s. Thymalin is a mixture of peptide extract; thymulin by contrast is a single, defined peptide of 9 amino acids whose biological activity requires zinc binding. It is crucial to T-cell differentiation and maturation inside the thymus. Serum levels fall significantly with age and with zinc deficiency, feeding age-related immune decline (immunosenescence). Research has looked at restoring immune function, managing autoimmune conditions, and use as an anti-inflammatory agent.

Khavinson bioregulator dipeptide (KE) of lysine and glutamic acid, isolated originally from thymus gland extracts. Professor Vladimir Khavinson developed it at the St. Petersburg Institute of Bioregulation and Gerontology; it works as a molecular signaling compound, restoring normal gene expression and protein synthesis in immune and epithelial cells. Animal studies record mean lifespan raised by 20–40% and tumor development suppressed.

Neuropeptide of 28 amino acids in the glucagon/secretin superfamily. Production occurs in many tissues, the gut, pancreas, and brain among them. Its vasodilatory, anti-inflammatory, and immunomodulatory effects are potent. Binding at the VPAC1 and VPAC2 receptors triggers cAMP-mediated signaling cascades. Research points to therapeutic potential for pulmonary hypertension, diabetes, neurological disorders, and autoimmune conditions.

The one human cathelicidin antimicrobial peptide: 37 amino acids, cationic, derived from hCAP18. Antimicrobial activity is broad-spectrum across bacteria, viruses, and fungi, and immune responses are modulated alongside it.

Natural peptide bioregulator from calf thymus gland, developed in the Soviet Union during the 1970s. Its mixture of thymic peptides supports immune restoration, anti-aging, and tissue regeneration. Decades of research have shown significant geroprotective effects: mortality rates fell up to 2-fold in studies, and 4-fold in combination with Epithalamin.